Congress Program

Wednesday, 2nd May

8:45 - 9:00

Opening remarks

9:00 – 9:45

Opening keynote talk

Chairs: Itamar Raz, Michael Walker

Insulins and insulin actions in unexpected places - Implications in pathogenesis of diabetes and its complications

C. Ron Kahn, Joslin Diabetes Center, Harvard Medical School, Boston, USA

9:45 -11:00

Session 1
Beta cell function and dysfunction in diabetes

Chairs: Itamar Raz, Michael Walker

9:45 – 10:15

Eliminate bad beta cells to prevent T1D

Anil Bhushan, Diabetes Center, School of Medicine, University of California San Francisco, USA

10:15 – 10:45

Organelle dysfunction in pancreatic beta cells in type 2 diabetes: lessons learned from monogenic forms of diabetes

Miriam Cnop, ULB Center for Diabetes Research, Universite Libre de Bruxelles, Brussels, Belgium

10:45 – 11:00

Human Beta and Alpha cell maturation, cellular plasticity and rare cell states:  A single cell transcriptome analysis

Dana Avrahami, Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

11:00 – 11:20

Coffee break

11:20- 13:40

Session 2
Heterogeneity in the pancreas

Chairs: Sara Ferber, Ron Piran

11:20 – 11:50

 The pericyte/beta-cell axis in glucose regulation

Limor Landsman, Dept. of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, Israel

11:50 – 12:20

Single molecule approaches for studying transcriptional heterogeneity in the intact pancreas

Shalev Itzkovitz, Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 

12:20 – 13:40

Panel discussion

Mechanisms of beta-cell failure in diabetes 

ModeratorBenjamin Glaser (Israel)
:  C. Ronald Kahn (usa), Anil Bhushan (USA), Miriam Cnop (Belgium), Gil Leibowitz (Israel)

13:40 – 15:00

Lunch & poster

15:00 – 17:00

Session 3
Genes and environment

Chairs: Hannah Kanety, Danny Ben Zvi

15:00 – 15:30

Mitochondrial-nuclear cross talk – an overlooked phenotypic impact

Dan Mishmar, Department Of Life Sciences. Head, Center for Evolutionary Genomics and Medicine, Ben-Gurion University of the Negev, Beer Sheva, Israel

15:30 – 16:00

The role of cell-cell communication in tissue propagation of ER stress in obesity

Amir Tirosh, Sackler School of Medicine, Tel-Aviv University. Institute of Endocrinology, Sheba Medical Center, Israel

16:00  - 16:15

miR-17-92/106b Regulate Beta Cell Mitotic Checkpoint and Insulin Secretion

Amitai Daniel Mandelbaum, Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

16:15 - 17:00

Closing keynote talk

CNS-dependent control of metabolism

Jens Bruening, Max Planck Institute for Metabolism Research, Cologne, Germany